Assay Detail
Functional
CHEMBL5554813
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Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovering New Metallo-Deubiquitinase CSN5 Inhibitors by a Non-Catalytic Activity Assay Platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.62 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | — | 1 | 6.16 |
| CHEMBL28457 | ALKANNIN | — | 1 | 5.85 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | — | 1 | 5.77 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 5.72 |
| CHEMBL486627 | DEOXYSHIKONIN | — | 1 | 5.17 |
| CHEMBL274056 | NAPHTHAZALIN | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL28457 | ALKANNIN | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL486627 | DEOXYSHIKONIN | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL274056 | NAPHTHAZALIN | IC50 | = | 8850.0 | nM | 5.05 |