Assay Detail

CHEMBL5576503

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Toxicity

Inhibition of human Cathepsin S

ChEMBL ↗

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Target

Cathepsin S (CHEMBL2954) ↗

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Primary target Cathepsin S

CHEMBL2954

Anchored from Assay target.

Protein identity Cathepsin S

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cathepsin S (CHEMBL2954) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.

Allerton CMN, Arcari JT, Aschenbrenner LM, Avery M, Bechle BM, Behzadi MA, Boras B, Buzon LM, Cardin RD, Catlin NR, Carlo AA, Coffman KJ, Dantonio A, Di L, Eng H, Farley KA, Ferre RA, Gernhardt SS, Gibson SA, Greasley SE, Greenfield SR, Hurst BL, Kalgutkar AS, Kimoto E, Lanyon LF, Lovett GH, Lian Y, Liu W, Martínez Alsina LA, Noell S, Obach RS, Owen DR, Patel NC, Rai DK, Reese MR, Rothan HA, Sakata S, Sammons MF, Sathish JG, Sharma R, Steppan CM, Tuttle JB, Verhoest PR, Wei L, Yang Q, Yurgelonis I, Zhu Y.
J Med Chem (2024) 67 : 13550 -13571
PubMed 38687966 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.48	7.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5591580	IBUZATRELVIR	2.0	1	7.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5591580	IBUZATRELVIR	IC50	=	33.0	nM	7.48