Assay Detail
Functional
CHEMBL5576557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
33
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.64 | 5.39 |
| Activity | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.39 |
| CHEMBL5594744 | — | — | 1 | 5.24 |
| CHEMBL5583671 | — | — | 1 | 5.19 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 5.10 |
| CHEMBL5590468 | — | — | 1 | 4.97 |
| CHEMBL5594900 | — | — | 1 | 4.87 |
| CHEMBL5593558 | — | — | 1 | 4.86 |
| CHEMBL5584080 | — | — | 1 | 4.73 |
| CHEMBL5583634 | — | — | 1 | 4.60 |
| CHEMBL5592087 | — | — | 1 | 4.58 |
| CHEMBL5593866 | — | — | 1 | 4.54 |
| CHEMBL5595712 | — | — | 1 | 4.51 |
| CHEMBL5592703 | — | — | 1 | 4.48 |
| CHEMBL5590227 | — | — | 1 | 4.47 |
| CHEMBL5591090 | — | — | 1 | 4.46 |
| CHEMBL5593906 | — | — | 1 | 4.37 |
| CHEMBL5592562 | — | — | 1 | 4.33 |
| CHEMBL5591318 | — | — | 1 | 4.30 |
| CHEMBL5591382 | — | — | 1 | 4.29 |
| CHEMBL5590177 | — | — | 1 | 4.28 |
| CHEMBL5592853 | — | — | 1 | 4.23 |
| CHEMBL5591158 | — | — | 1 | 4.19 |
| CHEMBL5591093 | — | — | 1 | - |
| CHEMBL5593967 | — | — | 1 | - |
| CHEMBL5589714 | — | — | 1 | - |
| CHEMBL5595626 | — | — | 1 | - |
| CHEMBL5584013 | — | — | 1 | - |
| CHEMBL5594145 | — | — | 1 | - |
| CHEMBL5593504 | — | — | 1 | - |
| CHEMBL5590658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5594744 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5583671 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5590468 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5594900 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL5593558 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL5584080 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL5583634 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL5592087 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL5593866 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL5595712 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL5592703 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL5590227 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL5591090 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL5593906 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL5592562 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL5591318 | — | IC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL5591382 | — | IC50 | = | 51400.0 | nM | 4.29 |
| CHEMBL5590177 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL5592853 | — | IC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL5591158 | — | IC50 | = | 64900.0 | nM | 4.19 |
| CHEMBL5591093 | — | Activity | - | — | - | |
| CHEMBL5593967 | — | Activity | - | — | - | |
| CHEMBL5589714 | — | Activity | - | — | - | |
| CHEMBL5595626 | — | Activity | - | — | - | |
| CHEMBL5584013 | — | Activity | - | — | - | |
| CHEMBL5594145 | — | Activity | - | — | - | |
| CHEMBL5593504 | — | Activity | - | — | - | |
| CHEMBL5590658 | — | Activity | - | — | - | |
| CHEMBL1619 | CLADRIBINE | IC50 | < | 100.0 | nM | - |
| CHEMBL5593557 | — | Activity | - | — | - | |
| CHEMBL5594130 | — | Activity | - | — | - |