Assay Detail
Functional
CHEMBL5576559
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Cytotoxicity against human Hep3B cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 7.00 |
| CHEMBL5590468 | — | — | 1 | 4.99 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5590468 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 27800.0 | nM | 4.56 |