Assay Detail
Functional
CHEMBL5576843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 4 days by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
The role of the methoxy group in approved drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.51 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301620 | TEMSAVIR | 2.0 | 1 | 9.85 |
| CHEMBL5591873 | — | — | 1 | 9.55 |
| CHEMBL2315655 | — | — | 1 | 9.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301620 | TEMSAVIR | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL5591873 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL2315655 | — | EC50 | = | 0.76 | nM | 9.12 |