Assay Detail
Functional
CHEMBL5576845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 HTLV-IIIB infected in human MT4 cells assessed as reduction in virus induced cytopathic effect by immunofluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
The role of the methoxy group in approved drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.72 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105735 | ASUNAPREVIR | 4.0 | 1 | 8.22 |
| CHEMBL3125106 | — | — | 1 | 7.72 |
| CHEMBL5594789 | — | — | 1 | 7.70 |
| CHEMBL3128331 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105735 | ASUNAPREVIR | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3125106 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5594789 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3128331 | — | EC50 | = | 60.0 | nM | 7.22 |