Assay Detail
Binding
CHEMBL5576848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 (unknown origin) (575 to 869 residues) by HTRF assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The role of the methoxy group in approved drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.48 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4524832 | — | — | 1 | 9.22 |
| CHEMBL4526283 | — | — | 1 | 9.04 |
| CHEMBL4460194 | — | — | 1 | 8.28 |
| CHEMBL4543090 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4524832 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4526283 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4460194 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4543090 | — | IC50 | = | 44.0 | nM | 7.36 |