Assay Detail
Binding
CHEMBL5576849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The role of the methoxy group in approved drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.44 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 9.70 |
| CHEMBL4571117 | — | — | 1 | 9.52 |
| CHEMBL4557190 | — | — | 1 | 9.40 |
| CHEMBL4476261 | — | — | 1 | 9.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4571117 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4557190 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4476261 | — | IC50 | = | 0.7 | nM | 9.15 |