Assay Detail
Functional
CHEMBL5577016
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Antiproliferative activity against human K562 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 5.33 |
| CHEMBL5593061 | — | — | 1 | 5.21 |
| CHEMBL5593648 | — | — | 1 | 4.35 |
| CHEMBL5595575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5593061 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5593648 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL5595575 | — | IC50 | > | 50000.0 | nM | - |