Assay Detail
Functional
CHEMBL5577192
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Antiproliferative activity against human PC-9 cells harboring EGFR Del19 mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploring the structural activity relationship of the Osimertinib: A covalent inhibitor of double mutant EGFR<sup>L858R/T790M</sup> tyrosine kinase for the treatment of Non-Small Cell Lung Cancer (NSCLC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.36 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353404 | — | — | 1 | 8.70 |
| CHEMBL3353403 | — | — | 1 | 7.80 |
| CHEMBL3353405 | — | — | 1 | 7.68 |
| CHEMBL3353396 | — | — | 1 | 7.55 |
| CHEMBL3353395 | — | — | 1 | 7.14 |
| CHEMBL3353399 | — | — | 1 | 6.81 |
| CHEMBL3353400 | — | — | 1 | 6.75 |
| CHEMBL3353402 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353404 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3353403 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3353405 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3353396 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3353395 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3353399 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3353400 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL3353402 | — | IC50 | = | 351.0 | nM | 6.46 |