Assay Detail
Functional
CHEMBL5577205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC-9 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploring the structural activity relationship of the Osimertinib: A covalent inhibitor of double mutant EGFR<sup>L858R/T790M</sup> tyrosine kinase for the treatment of Non-Small Cell Lung Cancer (NSCLC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.92 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591885 | — | — | 1 | 8.40 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.30 |
| CHEMBL5591648 | — | — | 1 | 7.52 |
| CHEMBL5592908 | — | — | 1 | 6.52 |
| CHEMBL5591941 | — | — | 1 | 6.10 |
| CHEMBL5590064 | — | — | 1 | 5.89 |
| CHEMBL5593646 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591885 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5591648 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5592908 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5591941 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5590064 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5593646 | — | IC50 | = | 1900.0 | nM | 5.72 |