Assay Detail
Binding
CHEMBL5577226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 6His-tagged human UCHL1 using Ub-Rh110Gly as fluorogenic substrate preincubated for 1 hr followed by substrate addition by plate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (CHEMBL6159) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of <i>Chlamydia trachomatis</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.34 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5589657 | — | — | 1 | 7.30 |
| CHEMBL5589694 | — | — | 1 | 5.38 |
| CHEMBL5590899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5589657 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5589694 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5590899 | — | IC50 | < | 1000.0 | nM | - |