Assay Detail
Binding
CHEMBL5577637
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Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 30 mins by absorbance based microplate reader analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and anti-melanogenic efficacy of 2-mercaptobenzoxazoles with nanomolar tyrosinase activity inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.81 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113414 | — | — | 1 | 7.10 |
| CHEMBL4856216 | — | — | 1 | 7.10 |
| CHEMBL4848849 | — | — | 1 | 7.05 |
| CHEMBL263376 | PHENYLTHIOUREA | — | 1 | 6.85 |
| CHEMBL5592049 | — | — | 1 | 5.67 |
| CHEMBL4867541 | — | — | 1 | 5.24 |
| CHEMBL4859482 | — | — | 1 | 5.20 |
| CHEMBL5590840 | — | — | 1 | 4.86 |
| CHEMBL5593933 | — | — | 1 | 4.62 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113414 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4856216 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4848849 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL263376 | PHENYLTHIOUREA | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5592049 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4867541 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL4859482 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL5590840 | — | IC50 | = | 13760.0 | nM | 4.86 |
| CHEMBL5593933 | — | IC50 | = | 23840.0 | nM | 4.62 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 35120.0 | nM | 4.45 |