Assay Detail
Binding
CHEMBL5577658
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Binding affinity to mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant by Dixon plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and anti-melanogenic efficacy of 2-mercaptobenzoxazoles with nanomolar tyrosinase activity inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.03 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113414 | — | — | 1 | 7.24 |
| CHEMBL4856216 | — | — | 1 | 7.01 |
| CHEMBL4848849 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113414 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL4856216 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL4848849 | — | Ki | = | 142.0 | nM | 6.85 |