Assay Detail
Binding
CHEMBL5577704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALK2 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.91 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513147 | — | — | 1 | 8.40 |
| CHEMBL4548795 | — | — | 1 | 7.89 |
| CHEMBL5083143 | — | — | 1 | 7.57 |
| CHEMBL5590609 | — | — | 1 | 5.44 |
| CHEMBL5303363 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513147 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4548795 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5083143 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5590609 | — | EC50 | = | 3601.0 | nM | 5.44 |
| CHEMBL5303363 | — | EC50 | = | 5686.0 | nM | 5.25 |