Assay Detail
Binding
CHEMBL5579355
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Inhibition of PANK3 (unknown origin) using D-[1-14C]pantothenate as substrate incubated for 10 mins in presence of ATP by scintillation counting analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 8.13 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082138 | — | — | 1 | 9.66 |
| CHEMBL5591518 | — | — | 1 | 9.22 |
| CHEMBL5593149 | — | — | 1 | 8.99 |
| CHEMBL5579772 | — | — | 1 | 8.92 |
| CHEMBL5077276 | — | — | 1 | 8.89 |
| CHEMBL5595360 | CLAZIPROTAMIDE | 2.0 | 1 | 8.86 |
| CHEMBL5595577 | — | — | 1 | 8.82 |
| CHEMBL5591881 | — | — | 1 | 8.80 |
| CHEMBL5583598 | — | — | 1 | 8.80 |
| CHEMBL5594834 | — | — | 1 | 8.66 |
| CHEMBL5593336 | — | — | 1 | 8.54 |
| CHEMBL5595254 | — | — | 1 | 8.42 |
| CHEMBL5583913 | — | — | 1 | 8.28 |
| CHEMBL5593309 | — | — | 1 | 8.28 |
| CHEMBL5595772 | — | — | 1 | 8.26 |
| CHEMBL5590794 | — | — | 1 | 8.24 |
| CHEMBL5583858 | — | — | 1 | 8.19 |
| CHEMBL5592936 | — | — | 1 | 8.16 |
| CHEMBL5591337 | — | — | 1 | 8.12 |
| CHEMBL5589594 | — | — | 1 | 8.05 |
| CHEMBL5592363 | — | — | 1 | 8.05 |
| CHEMBL5590407 | — | — | 1 | 8.05 |
| CHEMBL5595986 | — | — | 1 | 8.01 |
| CHEMBL5593608 | — | — | 1 | 7.90 |
| CHEMBL5592189 | — | — | 1 | 7.89 |
| CHEMBL5593897 | — | — | 1 | 7.78 |
| CHEMBL5592747 | — | — | 1 | 7.75 |
| CHEMBL5593435 | — | — | 1 | 7.72 |
| CHEMBL5591781 | — | — | 1 | 7.70 |
| CHEMBL5583789 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082138 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL5591518 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5593149 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL5579772 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5077276 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5595360 | CLAZIPROTAMIDE | IC50 | = | 1.39 | nM | 8.86 |
| CHEMBL5595577 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5591881 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5583598 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5594834 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5593336 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5595254 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5583913 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5593309 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5595772 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5590794 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5583858 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5592936 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5591337 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5589594 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5592363 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL5590407 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL5595986 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL5593608 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL5592189 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL5593897 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL5592747 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL5593435 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL5591781 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5583789 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5594484 | — | IC50 | = | 50.4 | nM | 7.30 |
| CHEMBL5592445 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5589863 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL5592464 | — | IC50 | = | 10370.0 | nM | 4.98 |