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Compound Detail

CHEMBL5590407

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O=C(Cc1ccc(CC(F)(F)F)cc1)N1CCN(c2ccc(Cl)nn2)CC1

Basic Information

ChEMBL ID CHEMBL5590407
Phase Preclinical
Structure Type MOL
InChI Key KRYVTZZZOKPCQN-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names

Molecular Properties

398.8
MW (Da)
3.13
ALogP
4
HBA
0
HBD
49.3
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H18ClF3N4O
MW 398.82
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -1.73

Activity Summary

IC50 1 meas. best 8.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Pantothenate kinase 3
CHEMBL3407328
IC50 8.05 8.05 8.9 1

Pharmacokinetic Data

Parameter Value Units Species
CL 165.0 mL.min-1.kg-1 Mus musculus
CL 19.0 mL.min-1.kg-1 Homo sapiens
T1/2 0.35 hr Mus musculus
T1/2 1.09 hr Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
39136313 10.1021/acs.jmedchem.4c01211 ADMET 4
39136313 10.1021/acs.jmedchem.4c01211 Unchecked 3
39136313 10.1021/acs.jmedchem.4c01211 Pantothenate kinase 3 2
39136313 10.1021/acs.jmedchem.4c01211 No relevant target 1

Data from ChEMBL 36 via Core Engine