Assay Detail
Functional
CHEMBL5579424
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Antiviral activity against Human coronavirus 229E infected in human MRC5 cells assessed as reduction in viral growth incubated for 68 hrs by CellTiter-Glo luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.63 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595779 | — | — | 1 | 8.70 |
| CHEMBL5583975 | — | — | 1 | 8.30 |
| CHEMBL5583748 | — | — | 1 | 8.15 |
| CHEMBL5583722 | — | — | 1 | 7.60 |
| CHEMBL5591147 | — | — | 1 | 7.52 |
| CHEMBL5589992 | — | — | 1 | 7.24 |
| CHEMBL1720448 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595779 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5583975 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5583748 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5583722 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5591147 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5589992 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1720448 | — | EC50 | = | 1360.0 | nM | 5.87 |