Assay Detail

CHEMBL5579445

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Toxicity

Neurotoxicity in human iPSC cells co-cultured with human astrocyte assessed as reduction in cell viability incubated for 1 hr by multi-electrode array analysis

ChEMBL ↗

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Target

ADMET (CHEMBL612558) ↗

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Primary target ADMET

CHEMBL612558

Anchored from Assay target.

Protein identity ADMET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Homo sapiens
Cell Type	iPSC
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

ADMET (CHEMBL612558) ↗

Type

ADMET

Publication

Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety.

Pero JE, Mueller EA, Adams AM, Adolph RS, Bagchi P, Balce D, Bantscheff M, Barauskas O, Bartha I, Bohan D, Cai H, Carabajal E, Cassidy J, Cato M, Chaudhary KW, Chen D, Chen YP, Colas C, Darwech I, Eberl HC, Fernandez B, Gordon E, Grosse J, Hansen J, Hetzler B, Hwang S, Jeyasingh S, Kowalski B, Lehmann S, Lo G, McAllaster M, McHugh C, Momont C, Newby Z, Nigro M, Oladunni F, Pannirselvam M, Park A, Pearson N, Peat AJ, Plastridge B, Ranjan R, Safabakhsh P, Shapiro ND, Soriaga L, Stokes N, Sweeney D, Talecki L, Telenti A, Terrell A, Tse W, Wang L, Wang S, Wedel L, Werner T, Dalmas Wilk D, Yim S, Zhou J.
J Med Chem (2024) 67 : 14586 -14608
PubMed 39136957 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.64	4.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5591147	—	—	1	4.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5591147	—	IC50	=	23000.0	nM	4.64