Assay Detail
Toxicity
CHEMBL5579508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length ADAMTS5 using FAM-Thr-Glu-Ser-Glu-Ser-Arg-Gly-Ala-Ile-Tyr-Lys-Lys-TAMRA as substrate by FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5 (CHEMBL2285) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.12 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595366 | — | — | 1 | 8.52 |
| CHEMBL5589746 | — | — | 1 | 8.52 |
| CHEMBL5591230 | — | — | 1 | 8.22 |
| CHEMBL5594088 | — | — | 1 | 8.05 |
| CHEMBL5593176 | — | — | 1 | 8.00 |
| CHEMBL5592306 | — | — | 1 | 7.82 |
| CHEMBL5593273 | — | — | 1 | 7.05 |
| CHEMBL5594880 | — | — | 1 | 7.05 |
| CHEMBL5589804 | — | — | 1 | 6.96 |
| CHEMBL5593591 | — | — | 1 | 5.42 |
| CHEMBL5590061 | — | — | 1 | 4.96 |
| CHEMBL5592123 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595366 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5589746 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5591230 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL5594088 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL5593176 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL5592306 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL5593273 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL5594880 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL5589804 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL5593591 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL5590061 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL5592123 | — | Ki | = | 13000.0 | nM | 4.89 |