Assay Detail
Functional
CHEMBL5579978
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural products fragment-based design and synthesis of a novel pentacyclic ring system as potential MAPK inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.25 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5593733 | — | — | 1 | 6.48 |
| CHEMBL5589793 | — | — | 1 | 6.40 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.19 |
| CHEMBL2064573 | BENZO[K]TRYPTANTHRIN | — | 1 | 4.87 |
| CHEMBL5584023 | — | — | 1 | 4.83 |
| CHEMBL5590126 | — | — | 1 | 4.60 |
| CHEMBL5593198 | — | — | 1 | 4.36 |
| CHEMBL5595762 | — | — | 1 | - |
| CHEMBL5594146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5593733 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5589793 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL939 | GEFITINIB | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL2064573 | BENZO[K]TRYPTANTHRIN | IC50 | = | 13540.0 | nM | 4.87 |
| CHEMBL5584023 | — | IC50 | = | 14970.0 | nM | 4.83 |
| CHEMBL5590126 | — | IC50 | = | 25220.0 | nM | 4.60 |
| CHEMBL5593198 | — | IC50 | = | 43210.0 | nM | 4.36 |
| CHEMBL5595762 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5594146 | — | IC50 | > | 100000.0 | nM | - |