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Assay Detail

CHEMBL5580016

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ICOS/ICOSL (unknown origin) interaction by ELISA method
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

ICOS-ICOSL (CHEMBL5482971)
Type PROTEIN-PROTEIN INTERACTION
Organism Homo sapiens

Publication

Design of cyclic peptides as novel inhibitors of ICOS/ICOSL interaction.
Abdel-Rahman SA, Santini BL, Calvo-Barreiro L, Zacharias M, Gabr M.
Bioorg Med Chem Lett (2024) 99 : 129599 -129599
PubMed 38185345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Inhibition 2 - -
IC50 1 5.73 5.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5591374 1 5.73
CHEMBL5592269 1 -
CHEMBL5590462 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5591374 IC50 = 1870.0 nM 5.73
CHEMBL5592269 Inhibition - % -
CHEMBL5590462 Inhibition - % -