ICOS-ICOSL · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O75144. Use UniProt O75144 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O75144 as the stable identity anchor, then attach disease evidence before program review.
ICOS ligand
Review this target as ICOS-ICOSL, mapped to UniProt O75144. ChEMBL maps the protein component as ICOS ligand. Sequence length is 302 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ICOS-ICOSL as ChEMBL target CHEMBL5482971, mapped to UniProt O75144. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether ICOS-ICOSL is the right protein anchor across sources, using UniProt O75144 as the stable mapping.
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| Preferred Name | ICOS-ICOSL |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | O75144 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | ICOS ligand |
| UniProt Accession | O75144 |
| Component Type | Protein |
| Sequence Length | 302 aa |
ICOS ligand
Review this target as ICOS-ICOSL, mapped to UniProt O75144. ChEMBL maps the protein component as ICOS ligand. Sequence length is 302 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5591374 | 5.73 | IC50 | 1870.0 | Preclinical |
| CHEMBL5592269 | 5.43 | IC50 | 3680.0 | Preclinical |
| CHEMBL2171562 | 5.33 | IC50 | 4680.0 | Preclinical |
| CHEMBL5429501 | 5.25 | IC50 | 5650.0 | Preclinical |
| CHEMBL608154 | 4.99 | IC50 | 10320.0 | Preclinical |
| CHEMBL5404661 | 4.96 | IC50 | 11080.0 | Preclinical |
| CHEMBL79004 | 4.86 | IC50 | 13890.0 | Preclinical |
| CHEMBL2171561 | 4.81 | IC50 | 15510.0 | Preclinical |
| CHEMBL2171563 | 4.74 | IC50 | 18350.0 | Preclinical |
| CHEMBL78917 | 4.54 | IC50 | 28640.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 5 | 15 | 4.9 |
| cell-based format | 1 | 0 | — |