Compound Detail
CHEMBL5429501
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Basic Information
| ChEMBL ID | CHEMBL5429501 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SBNNIWTYDATTAO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
367.8
MW (Da)
3.73
ALogP
5
HBA
2
HBD
92.8
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ICOS-ICOSL CHEMBL5482971 | IC50 | 5.25 | 5.25 | 5650.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ICOS-ICOSL | IC50 | = | 5650.0 | nM | 5.25 | Inhibition of C-terminal IgG1 Fc region fused human ICOS extracellular domain (1... | 37731692 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37731692 | 10.1039/d3md00150d | ICOS-ICOSL | 1 |
Data from ChEMBL 36 via Core Engine