Assay Detail
Binding
CHEMBL5580096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha-Synuclein (unknown origin) aggregation assessed as aggregation inhibition ratio measured after 72 hrs by Thioflavin T based fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic potential of Coumarin-polyphenolic acid hybrids in PD: Inhibition of α-Syn aggregation and disaggregation of preformed fibrils, leading to reduced neuronal inclusion formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.99 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5593502 | — | — | 1 | 6.20 |
| CHEMBL5583798 | — | — | 1 | 6.17 |
| CHEMBL5595203 | — | — | 1 | 6.01 |
| CHEMBL5594378 | — | — | 1 | 5.99 |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5593502 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5583798 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5595203 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5594378 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | = | 2580.0 | nM | 5.59 |