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Assay Detail

CHEMBL5581203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine liver beta-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol by spectrometric analysis
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glucosylceramidase (CHEMBL1275219)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives.
Gao FT, Wu QK, Zhang M, Shimadate Y, Qian G, Song YY, Kato A, Li YX, Jia YM, Fleet GWJ, Yu CY.
Eur J Med Chem (2024) 275 : 116570 -116570
PubMed 38878517 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 6.61 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5592849 1 8.70
CHEMBL5589663 1 8.40
CHEMBL5589982 1 8.40
CHEMBL5593532 1 8.40
CHEMBL5595884 1 8.10
CHEMBL5591684 1 8.10
CHEMBL5591053 1 8.00
CHEMBL5595646 1 7.92
CHEMBL5590768 1 7.92
CHEMBL5592633 1 7.43
CHEMBL5593747 1 7.43
CHEMBL5594749 1 7.33
CHEMBL5593833 1 7.27
CHEMBL5593449 1 7.25
CHEMBL5593397 1 7.19
CHEMBL5592010 1 7.11
CHEMBL5595101 1 6.92
CHEMBL5593098 1 6.80
CHEMBL5595932 1 6.80
CHEMBL5595189 1 6.57
CHEMBL5595451 1 6.54
CHEMBL5592567 1 6.52
CHEMBL5590717 1 6.29
CHEMBL5594775 1 6.21
CHEMBL5590889 1 6.12
CHEMBL5594705 1 6.03
CHEMBL5594464 1 5.57
CHEMBL5593790 1 5.25
CHEMBL5593507 1 5.20
CHEMBL5592931 1 5.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5592849 IC50 = 2.0 nM 8.70
CHEMBL5589663 IC50 = 4.0 nM 8.40
CHEMBL5593532 IC50 = 4.0 nM 8.40
CHEMBL5589982 IC50 = 4.0 nM 8.40
CHEMBL5595884 IC50 = 8.0 nM 8.10
CHEMBL5591684 IC50 = 8.0 nM 8.10
CHEMBL5591053 IC50 = 10.0 nM 8.00
CHEMBL5595646 IC50 = 12.0 nM 7.92
CHEMBL5590768 IC50 = 12.0 nM 7.92
CHEMBL5592633 IC50 = 37.0 nM 7.43
CHEMBL5593747 IC50 = 37.0 nM 7.43
CHEMBL5594749 IC50 = 47.0 nM 7.33
CHEMBL5593833 IC50 = 54.0 nM 7.27
CHEMBL5593449 IC50 = 56.0 nM 7.25
CHEMBL5593397 IC50 = 65.0 nM 7.19
CHEMBL5592010 IC50 = 77.0 nM 7.11
CHEMBL5595101 IC50 = 120.0 nM 6.92
CHEMBL5593098 IC50 = 160.0 nM 6.80
CHEMBL5595932 IC50 = 160.0 nM 6.80
CHEMBL5595189 IC50 = 270.0 nM 6.57
CHEMBL5595451 IC50 = 290.0 nM 6.54
CHEMBL5592567 IC50 = 300.0 nM 6.52
CHEMBL5590717 IC50 = 510.0 nM 6.29
CHEMBL5594775 IC50 = 620.0 nM 6.21
CHEMBL5590889 IC50 = 760.0 nM 6.12
CHEMBL5594705 IC50 = 930.0 nM 6.03
CHEMBL5594464 IC50 = 2700.0 nM 5.57
CHEMBL5593790 IC50 = 5600.0 nM 5.25
CHEMBL5593507 IC50 = 6300.0 nM 5.20
CHEMBL5592931 IC50 = 7500.0 nM 5.12
CHEMBL5590791 IC50 = 12000.0 nM 4.92
CHEMBL5594010 IC50 = 16000.0 nM 4.80
CHEMBL5593542 IC50 = 24000.0 nM 4.62
CHEMBL5593187 IC50 = 34000.0 nM 4.47
CHEMBL5592225 IC50 = 67000.0 nM 4.17
CHEMBL5594426 IC50 = 71000.0 nM 4.15
CHEMBL5594117 IC50 = 113000.0 nM -
CHEMBL5589776 IC50 = 135000.0 nM -
CHEMBL5595529 IC50 = 102000.0 nM -