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Assay Detail

CHEMBL5581284

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV-based lentiviral pseudotyped Marburgvirus harboring mucin domain deleted GP infected in HEK293T cells assessed as inhibition of viral entry preincubated with virus for 1 hr followed by cell infection and measured after 48 hrs by luminescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Marburgvirus
Cell Type HEK293T
Confidence 1 — Organism
Curated By Autocuration

Target

Marburgvirus (CHEMBL4296577)
Type ORGANISM
Organism Marburgvirus

Publication

(+)-fenchol and (-)-isopinocampheol derivatives targeting the entry process of filoviruses.
Sokolova AS, Baev DS, Mordvinova ED, Yarovaya OI, Volkova NV, Shcherbakov DN, Okhina AA, Rogachev AD, Shnaider TA, Chvileva AS, Nikitina TV, Tolstikova TG, Salakhutdinov NF.
Eur J Med Chem (2024) 275 : 116596 -116596
PubMed 38889610 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 4.70 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1655 TOREMIFENE 4.0 1 6.16
CHEMBL5592940 1 5.22
CHEMBL5592964 1 5.14
CHEMBL5595146 1 5.05
CHEMBL5591747 1 4.95
CHEMBL5590446 1 4.89
CHEMBL5591685 1 4.86
CHEMBL5591441 1 4.75
CHEMBL5592840 1 4.69
CHEMBL5583953 1 4.68
CHEMBL5593695 1 4.66
CHEMBL5593652 1 4.62
CHEMBL5594623 1 4.62
CHEMBL5590104 1 4.60
CHEMBL5592638 1 4.60
CHEMBL5595960 1 4.58
CHEMBL5591011 1 4.57
CHEMBL5584026 1 4.56
CHEMBL5590891 1 4.54
CHEMBL5592994 1 4.52
CHEMBL5594482 1 4.51
CHEMBL5595696 1 4.41
CHEMBL5592622 1 4.32
CHEMBL5594558 1 4.25
CHEMBL5595942 1 4.19
CHEMBL5593990 1 4.17
CHEMBL5595280 1 -
CHEMBL5595631 1 -
CHEMBL5583989 1 -
CHEMBL5593073 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1655 TOREMIFENE IC50 = 700.0 nM 6.16
CHEMBL5592940 IC50 = 6000.0 nM 5.22
CHEMBL5592964 IC50 = 7300.0 nM 5.14
CHEMBL5595146 IC50 = 9000.0 nM 5.05
CHEMBL5591747 IC50 = 11300.0 nM 4.95
CHEMBL5590446 IC50 = 13000.0 nM 4.89
CHEMBL5591685 IC50 = 13900.0 nM 4.86
CHEMBL5591441 IC50 = 18000.0 nM 4.75
CHEMBL5592840 IC50 = 20400.0 nM 4.69
CHEMBL5583953 IC50 = 20700.0 nM 4.68
CHEMBL5593695 IC50 = 22000.0 nM 4.66
CHEMBL5593652 IC50 = 24000.0 nM 4.62
CHEMBL5594623 IC50 = 24000.0 nM 4.62
CHEMBL5590104 IC50 = 25000.0 nM 4.60
CHEMBL5592638 IC50 = 25000.0 nM 4.60
CHEMBL5595960 IC50 = 26400.0 nM 4.58
CHEMBL5591011 IC50 = 27000.0 nM 4.57
CHEMBL5584026 IC50 = 27500.0 nM 4.56
CHEMBL5590891 IC50 = 29000.0 nM 4.54
CHEMBL5592994 IC50 = 30100.0 nM 4.52
CHEMBL5594482 IC50 = 31000.0 nM 4.51
CHEMBL5595696 IC50 = 39000.0 nM 4.41
CHEMBL5592622 IC50 = 47600.0 nM 4.32
CHEMBL5594558 IC50 = 56000.0 nM 4.25
CHEMBL5595942 IC50 = 64400.0 nM 4.19
CHEMBL5593990 IC50 = 68000.0 nM 4.17
CHEMBL5595280 IC50 = 107000.0 nM -
CHEMBL5595631 IC50 = 156000.0 nM -
CHEMBL5583989 IC50 = 213000.0 nM -
CHEMBL5593073 IC50 = 164000.0 nM -