Assay Detail
Functional
CHEMBL5581286
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Antiviral activity against HIV-based lentiviral pseudotyped Marburgvirus harboring GP I627V mutant infected in HEK293T cells assessed as inhibition of viral entry preincubated with virus for 1 hr followed by cell infection and measured after 48 hrs by luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Marburgvirus |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(+)-fenchol and (-)-isopinocampheol derivatives targeting the entry process of filoviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.85 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591747 | — | — | 1 | 5.38 |
| CHEMBL5590446 | — | — | 1 | 5.34 |
| CHEMBL5591685 | — | — | 1 | 5.21 |
| CHEMBL5583953 | — | — | 1 | 5.08 |
| CHEMBL5592840 | — | — | 1 | 5.00 |
| CHEMBL5595960 | — | — | 1 | 4.85 |
| CHEMBL5584026 | — | — | 1 | 4.60 |
| CHEMBL5592994 | — | — | 1 | 4.52 |
| CHEMBL5592622 | — | — | 1 | 4.31 |
| CHEMBL5595942 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591747 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5590446 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5591685 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5583953 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5592840 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5595960 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5584026 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5592994 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5592622 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL5595942 | — | IC50 | = | 69100.0 | nM | 4.16 |