Assay Detail
Functional
CHEMBL5581292
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Antiviral activity against HIV-based lentiviral pseudotyped Ebolavirus harboring GP M548A mutant infected in HEK293T cells assessed as inhibition of viral entry preincubated with virus for 1 hr followed by cell infection and measured after 48 hrs by luminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(+)-fenchol and (-)-isopinocampheol derivatives targeting the entry process of filoviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.50 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595942 | — | — | 1 | 6.05 |
| CHEMBL5591747 | — | — | 1 | 6.05 |
| CHEMBL5584026 | — | — | 1 | 5.77 |
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 5.72 |
| CHEMBL5583953 | — | — | 1 | 5.51 |
| CHEMBL5590446 | — | — | 1 | 5.50 |
| CHEMBL5595960 | — | — | 1 | 5.47 |
| CHEMBL5591685 | — | — | 1 | 5.26 |
| CHEMBL5592994 | — | — | 1 | 5.24 |
| CHEMBL5592622 | — | — | 1 | 5.17 |
| CHEMBL5592840 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595942 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5591747 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5584026 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1655 | TOREMIFENE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5583953 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5590446 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5595960 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5591685 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5592994 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5592622 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5592840 | — | IC50 | = | 18700.0 | nM | 4.73 |