Assay Detail
Toxicity
CHEMBL5581356
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Hepatotoxicity in human HepG2 cells incubated for 24 hrs by PrestoBlue reagent based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual 5-HT<sub>6</sub>/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.38 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5594193 | — | — | 1 | 4.64 |
| CHEMBL5592369 | — | — | 1 | 4.51 |
| CHEMBL5593858 | — | — | 1 | 4.28 |
| CHEMBL5589768 | — | — | 1 | 4.08 |
| CHEMBL5592533 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5594193 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5592369 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL5593858 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5589768 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL5592533 | — | IC50 | > | 100000.0 | nM | - |