Assay Detail
Functional
CHEMBL5581448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1975 cells harboring EGFR double mutation
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new cyclopropane sulfonamide derivatives as EGFR inhibitors to overcome C797S-mediated resistance and EGFR double mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 9.85 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5590430 | — | — | 1 | 10.89 |
| CHEMBL5592293 | — | — | 1 | 10.62 |
| CHEMBL5584148 | — | — | 1 | 10.59 |
| CHEMBL5593035 | — | — | 1 | 10.46 |
| CHEMBL5592071 | — | — | 1 | 10.38 |
| CHEMBL5594458 | — | — | 1 | 10.36 |
| CHEMBL5594833 | — | — | 1 | 10.20 |
| CHEMBL5595676 | — | — | 1 | 10.14 |
| CHEMBL5590689 | — | — | 1 | 10.13 |
| CHEMBL5592255 | — | — | 1 | 10.08 |
| CHEMBL5592796 | — | — | 1 | 10.06 |
| CHEMBL5593632 | — | — | 1 | 10.02 |
| CHEMBL5593245 | — | — | 1 | 9.98 |
| CHEMBL5595208 | — | — | 1 | 9.97 |
| CHEMBL5593053 | — | — | 1 | 9.96 |
| CHEMBL5591001 | — | — | 1 | 9.91 |
| CHEMBL5595361 | — | — | 1 | 9.90 |
| CHEMBL5593247 | — | — | 1 | 9.82 |
| CHEMBL5584002 | — | — | 1 | 9.78 |
| CHEMBL5595788 | — | — | 1 | 9.71 |
| CHEMBL5592376 | — | — | 1 | 9.70 |
| CHEMBL5583875 | — | — | 1 | 9.63 |
| CHEMBL5595484 | — | — | 1 | 9.63 |
| CHEMBL5595478 | — | — | 1 | 9.57 |
| CHEMBL5591186 | — | — | 1 | 9.54 |
| CHEMBL5594461 | — | — | 1 | 9.53 |
| CHEMBL5593314 | — | — | 1 | 9.45 |
| CHEMBL5593051 | — | — | 1 | 9.40 |
| CHEMBL5594208 | — | — | 1 | 9.26 |
| CHEMBL5594296 | — | — | 1 | 9.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5590430 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL5592293 | — | IC50 | = | 0.024 | nM | 10.62 |
| CHEMBL5584148 | — | IC50 | = | 0.026 | nM | 10.59 |
| CHEMBL5593035 | — | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL5592071 | — | IC50 | = | 0.042 | nM | 10.38 |
| CHEMBL5594458 | — | IC50 | = | 0.044 | nM | 10.36 |
| CHEMBL5594833 | — | IC50 | = | 0.063 | nM | 10.20 |
| CHEMBL5595676 | — | IC50 | = | 0.072 | nM | 10.14 |
| CHEMBL5590689 | — | IC50 | = | 0.074 | nM | 10.13 |
| CHEMBL5592255 | — | IC50 | = | 0.084 | nM | 10.08 |
| CHEMBL5592796 | — | IC50 | = | 0.087 | nM | 10.06 |
| CHEMBL5593632 | — | IC50 | = | 0.095 | nM | 10.02 |
| CHEMBL5593245 | — | IC50 | = | 0.104 | nM | 9.98 |
| CHEMBL5595208 | — | IC50 | = | 0.106 | nM | 9.97 |
| CHEMBL5593053 | — | IC50 | = | 0.109 | nM | 9.96 |
| CHEMBL5591001 | — | IC50 | = | 0.123 | nM | 9.91 |
| CHEMBL5595361 | — | IC50 | = | 0.127 | nM | 9.90 |
| CHEMBL5593247 | — | IC50 | = | 0.152 | nM | 9.82 |
| CHEMBL5584002 | — | IC50 | = | 0.165 | nM | 9.78 |
| CHEMBL5595788 | — | IC50 | = | 0.195 | nM | 9.71 |
| CHEMBL5592376 | — | IC50 | = | 0.198 | nM | 9.70 |
| CHEMBL5583875 | — | IC50 | = | 0.236 | nM | 9.63 |
| CHEMBL5595484 | — | IC50 | = | 0.232 | nM | 9.63 |
| CHEMBL5595478 | — | IC50 | = | 0.266 | nM | 9.57 |
| CHEMBL5591186 | — | IC50 | = | 0.285 | nM | 9.54 |
| CHEMBL5594461 | — | IC50 | = | 0.295 | nM | 9.53 |
| CHEMBL5593314 | — | IC50 | = | 0.359 | nM | 9.45 |
| CHEMBL5593051 | — | IC50 | = | 0.394 | nM | 9.40 |
| CHEMBL5594208 | — | IC50 | = | 0.549 | nM | 9.26 |
| CHEMBL5594296 | — | IC50 | = | 0.642 | nM | 9.19 |
| CHEMBL5593280 | — | IC50 | = | 0.891 | nM | 9.05 |
| CHEMBL5595452 | — | IC50 | = | 0.915 | nM | 9.04 |
| CHEMBL5592057 | — | IC50 | = | 0.923 | nM | 9.04 |