Assay Detail
Binding
CHEMBL5581451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR T790M/L858R mutant (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new cyclopropane sulfonamide derivatives as EGFR inhibitors to overcome C797S-mediated resistance and EGFR double mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.42 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 9.47 |
| CHEMBL5590430 | — | — | 1 | 8.32 |
| CHEMBL5590689 | — | — | 1 | 7.99 |
| CHEMBL5594833 | — | — | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5590430 | — | IC50 | = | 4.76 | nM | 8.32 |
| CHEMBL5590689 | — | IC50 | = | 10.24 | nM | 7.99 |
| CHEMBL5594833 | — | IC50 | = | 12.57 | nM | 7.90 |