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Assay Detail

CHEMBL5581665

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of alpha-amylase (unknown origin) using 1% starch as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by colorimetric analysis
ChEMBL ↗
53
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Alpha amylase (CHEMBL6066863) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis of thiazolidine-2,4-dione tethered 1,2,3-triazoles as α-amylase inhibitors: In vitro approach coupled with QSAR, molecular docking, molecular dynamics and ADMET studies.
Singh R, Sindhu J, Devi M, Kumar P, Lal S, Kumar A, Singh D, Kumar H.
Eur J Med Chem (2024) 275 : 116623 -116623
PubMed 38943875 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 5.69 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5590766 — — 2 7.40
CHEMBL5593047 — — 2 7.35
CHEMBL5595096 — — 2 7.32
CHEMBL5595111 — — 2 7.32
CHEMBL5592906 — — 2 7.31
CHEMBL5592459 — — 2 7.28
CHEMBL5595454 — — 2 7.27
CHEMBL5593276 — — 2 7.26
CHEMBL5591259 — — 2 7.24
CHEMBL5592359 — — 2 7.23
CHEMBL5594054 — — 2 7.22
CHEMBL5590296 — — 2 7.21
CHEMBL5594825 — — 2 7.18
CHEMBL5596000 — — 2 7.18
CHEMBL5594396 — — 2 7.18
CHEMBL5595749 — — 2 7.17
CHEMBL5592466 — — 2 7.16
CHEMBL5592801 — — 2 7.11
CHEMBL5590293 — — 2 7.09
CHEMBL5592637 — — 2 7.08
CHEMBL5592947 — — 2 7.04
CHEMBL5594837 — — 2 7.03
CHEMBL5593659 — — 2 7.03
CHEMBL5595658 — — 2 7.01
CHEMBL5593920 — — 2 7.00
CHEMBL5592880 — — 2 6.86
CHEMBL404271 ACARBOSE 4.0 1 4.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5590766 — IC50 = 39.9 nM 7.40
CHEMBL5593047 — IC50 = 44.77 nM 7.35
CHEMBL5595096 — IC50 = 48.08 nM 7.32
CHEMBL5595111 — IC50 = 47.97 nM 7.32
CHEMBL5592906 — IC50 = 49.32 nM 7.31
CHEMBL5592459 — IC50 = 52.97 nM 7.28
CHEMBL5595454 — IC50 = 53.95 nM 7.27
CHEMBL5593276 — IC50 = 55.21 nM 7.26
CHEMBL5591259 — IC50 = 57.54 nM 7.24
CHEMBL5592359 — IC50 = 59.29 nM 7.23
CHEMBL5594054 — IC50 = 59.98 nM 7.22
CHEMBL5590296 — IC50 = 60.95 nM 7.21
CHEMBL5594396 — IC50 = 65.77 nM 7.18
CHEMBL5596000 — IC50 = 65.31 nM 7.18
CHEMBL5594825 — IC50 = 65.77 nM 7.18
CHEMBL5595749 — IC50 = 67.76 nM 7.17
CHEMBL5592466 — IC50 = 68.55 nM 7.16
CHEMBL5592801 — IC50 = 77.98 nM 7.11
CHEMBL5590293 — IC50 = 80.35 nM 7.09
CHEMBL5592637 — IC50 = 83.75 nM 7.08
CHEMBL5592947 — IC50 = 91.41 nM 7.04
CHEMBL5593659 — IC50 = 93.11 nM 7.03
CHEMBL5594837 — IC50 = 92.9 nM 7.03
CHEMBL5595658 — IC50 = 97.72 nM 7.01
CHEMBL5593920 — IC50 = 99.31 nM 7.00
CHEMBL5592880 — IC50 = 138.36 nM 6.86
CHEMBL404271 ACARBOSE IC50 = 28000.0 nM 4.55
CHEMBL5590766 — IC50 = 40000.0 nM 4.40
CHEMBL5593047 — IC50 = 45000.0 nM 4.35
CHEMBL5595111 — IC50 = 48000.0 nM 4.32
CHEMBL5595096 — IC50 = 48000.0 nM 4.32
CHEMBL5592906 — IC50 = 49000.0 nM 4.31
CHEMBL5592459 — IC50 = 53000.0 nM 4.28
CHEMBL5595454 — IC50 = 54000.0 nM 4.27
CHEMBL5593276 — IC50 = 55000.0 nM 4.26
CHEMBL5591259 — IC50 = 58000.0 nM 4.24
CHEMBL5592359 — IC50 = 59000.0 nM 4.23
CHEMBL5594054 — IC50 = 60000.0 nM 4.22
CHEMBL5590296 — IC50 = 61000.0 nM 4.21
CHEMBL5596000 — IC50 = 65000.0 nM 4.19
CHEMBL5594825 — IC50 = 66000.0 nM 4.18
CHEMBL5594396 — IC50 = 66000.0 nM 4.18
CHEMBL5595749 — IC50 = 68000.0 nM 4.17
CHEMBL5592466 — IC50 = 69000.0 nM 4.16
CHEMBL5592801 — IC50 = 78000.0 nM 4.11
CHEMBL5590293 — IC50 = 80000.0 nM 4.10
CHEMBL5592637 — IC50 = 84000.0 nM 4.08
CHEMBL5592947 — IC50 = 91000.0 nM 4.04
CHEMBL5593659 — IC50 = 93000.0 nM 4.03
CHEMBL5594837 — IC50 = 93000.0 nM 4.03