Assay Detail
Functional
CHEMBL5581840
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Antiproliferative activity against human MES-SA cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.97 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 9.40 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.96 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.47 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.31 |
| CHEMBL5589801 | — | — | 1 | 8.25 |
| CHEMBL5583620 | — | — | 1 | 8.20 |
| CHEMBL5589943 | — | — | 1 | 8.05 |
| CHEMBL5593374 | — | — | 1 | 8.05 |
| CHEMBL5594274 | — | — | 1 | 7.93 |
| CHEMBL5594310 | — | — | 1 | 7.91 |
| CHEMBL5593749 | — | — | 1 | 7.85 |
| CHEMBL5591933 | — | — | 1 | 7.75 |
| CHEMBL5593031 | — | — | 1 | 7.49 |
| CHEMBL5595105 | — | — | 1 | 7.09 |
| CHEMBL5591012 | — | — | 1 | 7.00 |
| CHEMBL5595113 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5589801 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL5583620 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5589943 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5593374 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL5594274 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL5594310 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL5593749 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL5591933 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL5593031 | — | IC50 | = | 32.5 | nM | 7.49 |
| CHEMBL5595105 | — | IC50 | = | 80.3 | nM | 7.09 |
| CHEMBL5591012 | — | IC50 | = | 99.9 | nM | 7.00 |
| CHEMBL5595113 | — | IC50 | = | 147.8 | nM | 6.83 |