Assay Detail
Functional
CHEMBL5581843
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Antiproliferative activity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.74 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 9.22 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.46 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.35 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.29 |
| CHEMBL5589801 | — | — | 1 | 8.19 |
| CHEMBL5591933 | — | — | 1 | 8.06 |
| CHEMBL5583620 | — | — | 1 | 7.93 |
| CHEMBL5589943 | — | — | 1 | 7.76 |
| CHEMBL5593374 | — | — | 1 | 7.66 |
| CHEMBL5594310 | — | — | 1 | 7.64 |
| CHEMBL5594274 | — | — | 1 | 7.48 |
| CHEMBL5593749 | — | — | 1 | 7.32 |
| CHEMBL5593031 | — | — | 1 | 7.30 |
| CHEMBL5595105 | — | — | 1 | 7.06 |
| CHEMBL5591012 | — | — | 1 | 6.61 |
| CHEMBL5595113 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5589801 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5591933 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5583620 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5589943 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL5593374 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL5594310 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL5594274 | — | IC50 | = | 33.2 | nM | 7.48 |
| CHEMBL5593749 | — | IC50 | = | 48.3 | nM | 7.32 |
| CHEMBL5593031 | — | IC50 | = | 49.8 | nM | 7.30 |
| CHEMBL5595105 | — | IC50 | = | 86.8 | nM | 7.06 |
| CHEMBL5591012 | — | IC50 | = | 245.3 | nM | 6.61 |
| CHEMBL5595113 | — | IC50 | = | 363.0 | nM | 6.44 |