Assay Detail
Binding
CHEMBL5581929
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NSD2 (unknown origin) by AlphaLISA assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase NSD2 (CHEMBL3108645) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.65 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5592280 | — | — | 1 | 7.92 |
| CHEMBL5592774 | — | — | 1 | 7.89 |
| CHEMBL5590338 | — | — | 1 | 7.85 |
| CHEMBL5593832 | — | — | 1 | 7.77 |
| CHEMBL5591131 | — | — | 1 | 7.77 |
| CHEMBL5589842 | — | — | 1 | 7.66 |
| CHEMBL5591835 | — | — | 1 | 7.57 |
| CHEMBL5583700 | — | — | 1 | 7.55 |
| CHEMBL5186268 | — | — | 1 | 6.96 |
| CHEMBL5422549 | — | — | 1 | 6.64 |
| CHEMBL5592600 | — | — | 1 | 6.58 |
| CHEMBL5595912 | — | — | 1 | 6.52 |
| CHEMBL5591832 | — | — | 1 | 6.44 |
| CHEMBL5594410 | — | — | 1 | 6.38 |
| CHEMBL5593211 | — | — | 1 | 6.36 |
| CHEMBL5591500 | — | — | 1 | 6.10 |
| CHEMBL5593275 | — | — | 1 | 6.01 |
| CHEMBL5592239 | — | — | 1 | 5.96 |
| CHEMBL5595949 | — | — | 1 | 5.96 |
| CHEMBL5590208 | — | — | 1 | 5.89 |
| CHEMBL5592452 | — | — | 1 | 5.85 |
| CHEMBL5592412 | — | — | 1 | 5.78 |
| CHEMBL5592107 | — | — | 1 | 5.74 |
| CHEMBL5589782 | — | — | 1 | 5.58 |
| CHEMBL5028132 | — | — | 1 | 5.57 |
| CHEMBL5591791 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5592280 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5592774 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5590338 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5593832 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5591131 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5589842 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5591835 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5583700 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5186268 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5422549 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5592600 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL5595912 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5591832 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL5594410 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL5593211 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL5591500 | — | IC50 | = | 792.0 | nM | 6.10 |
| CHEMBL5593275 | — | IC50 | = | 983.0 | nM | 6.01 |
| CHEMBL5592239 | — | IC50 | = | 1088.0 | nM | 5.96 |
| CHEMBL5595949 | — | IC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL5590208 | — | IC50 | = | 1289.0 | nM | 5.89 |
| CHEMBL5592452 | — | IC50 | = | 1407.0 | nM | 5.85 |
| CHEMBL5592412 | — | IC50 | = | 1645.0 | nM | 5.78 |
| CHEMBL5592107 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5589782 | — | IC50 | = | 2647.0 | nM | 5.58 |
| CHEMBL5028132 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5591791 | — | IC50 | < | 100.0 | nM | - |