Assay Detail
Binding
CHEMBL5581999
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Inhibition of TRKC (unknown origin) using TK as substrate incubated for 40 mins in presence of ATP by HTRF assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel indazole derivatives as second-generation TRK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 9.00 |
| CHEMBL5594048 | — | — | 1 | 8.70 |
| CHEMBL5594742 | — | — | 1 | 8.52 |
| CHEMBL5590602 | — | — | 1 | 8.52 |
| CHEMBL5593896 | — | — | 1 | 8.40 |
| CHEMBL5594862 | — | — | 1 | 8.22 |
| CHEMBL5592878 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5594048 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5594742 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5590602 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5593896 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5594862 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5592878 | — | IC50 | = | 6.0 | nM | 8.22 |