Compound Detail
CHEMBL5590602
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Basic Information
| ChEMBL ID | CHEMBL5590602 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UWXAGMXVWDWRRX-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
346.3
MW (Da)
3.83
ALogP
4
HBA
2
HBD
73.7
PSA (Ų)
0.71
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NT-3 growth factor receptor CHEMBL5608 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 8.0 | 7.235 | 10.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NT-3 growth factor receptor | IC50 | = | 3.0 | nM | 8.52 | Inhibition of TRKC (unknown origin) using TK as substrate incubated for 40 mins ... | 39033612 |
| High affinity nerve growth factor receptor | IC50 | = | 10.0 | nM | 8.0 | Inhibition of TRKA F589L mutant (unknown origin) using TK as substrate incubated... | 39033612 |
| High affinity nerve growth factor receptor | IC50 | = | 30.0 | nM | 7.52 | Inhibition of TRKA G595R mutant (unknown origin) using TK as substrate incubated... | 39033612 |
| High affinity nerve growth factor receptor | IC50 | = | 32.0 | nM | 7.5 | Inhibition of TRKA (unknown origin) using TK as substrate incubated for 30 mins ... | 39033612 |
| High affinity nerve growth factor receptor | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of TRKA G667C mutant (unknown origin) using TK as substrate incubated... | 39033612 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39033612 | 10.1016/j.ejmech.2024.116640 | High affinity nerve growth factor receptor | 4 |
| 39033612 | 10.1016/j.ejmech.2024.116640 | NT-3 growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine