Assay Detail
Functional
CHEMBL5582001
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Antiproliferative activity against mouse BaF3 cells expressing TRKA G595R mutant incubated for 72 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel indazole derivatives as second-generation TRK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.48 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5592878 | — | — | 1 | 8.33 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 7.92 |
| CHEMBL5594862 | — | — | 1 | 7.89 |
| CHEMBL5594048 | — | — | 1 | 7.26 |
| CHEMBL5593896 | — | — | 1 | 6.88 |
| CHEMBL5594742 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5592878 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5594862 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5594048 | — | IC50 | = | 54.5 | nM | 7.26 |
| CHEMBL5593896 | — | IC50 | = | 131.8 | nM | 6.88 |
| CHEMBL5594742 | — | IC50 | = | 253.9 | nM | 6.59 |