Assay Detail
Functional
CHEMBL5582002
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Antiproliferative activity against mouse BaF3 cells expressing TRKA G667C mutant incubated for 72 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel indazole derivatives as second-generation TRK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.19 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5592878 | — | — | 1 | 8.00 |
| CHEMBL5594862 | — | — | 1 | 7.37 |
| CHEMBL5594048 | — | — | 1 | 7.19 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 6.95 |
| CHEMBL5593896 | — | — | 1 | 6.87 |
| CHEMBL5594742 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5592878 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL5594862 | — | IC50 | = | 42.8 | nM | 7.37 |
| CHEMBL5594048 | — | IC50 | = | 64.1 | nM | 7.19 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 113.1 | nM | 6.95 |
| CHEMBL5593896 | — | IC50 | = | 136.2 | nM | 6.87 |
| CHEMBL5594742 | — | IC50 | = | 165.7 | nM | 6.78 |