Assay Detail
Binding
CHEMBL5582668
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Binding affinity to MDM2 (unknown origin) assessed as dissociation constant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cellular, Structural Basis, and Recent Progress for Targeting Murine Double Minute X (MDMX) in Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.37 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | — | 1 | 7.70 |
| CHEMBL5592613 | — | — | 1 | 6.70 |
| CHEMBL5595055 | — | — | 1 | 6.52 |
| CHEMBL3735996 | — | — | 1 | 5.75 |
| CHEMBL3735566 | — | — | 1 | 5.17 |
| CHEMBL5180980 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL5592613 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL5595055 | — | Kd | = | 300.0 | nM | 6.52 |
| CHEMBL3735996 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL3735566 | — | Kd | = | 6700.0 | nM | 5.17 |
| CHEMBL5180980 | — | Kd | < | 0.1 | nM | - |