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Assay Detail

CHEMBL5582732

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of cell proliferation in human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma.
Jana S, Shang J, Hong JY, Fenwick MK, Puri R, Lu X, Melnick AM, Li M, Lin H.
J Med Chem (2024) 67 : 15428 -15437
PubMed 39191393 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.35 5.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5595804 1 5.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5595804 IC50 = 4500.0 nM 5.35