Assay Detail
Binding
CHEMBL5582987
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Binding affinity to double stranded DNA AT12 (unknown origin) incubated for 0.5 hrs in presence of different concentration DNA by fluorescence spectra analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A Comparative Study on the DNA Interactions and Biological Activities of Benzophenanthridine and Protoberberine Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.82 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295124 | BERBERINE | 4.0 | 1 | 6.89 |
| CHEMBL5594821 | — | — | 1 | 6.66 |
| CHEMBL13045 | CHELERYTHRINE | — | 1 | 5.68 |
| CHEMBL5593587 | — | — | 1 | 5.55 |
| CHEMBL417799 | SANGUINARIUM | 2.0 | 1 | 5.38 |
| CHEMBL362071 | COPTISINE | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295124 | BERBERINE | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5594821 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL13045 | CHELERYTHRINE | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL5593587 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL417799 | SANGUINARIUM | EC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL362071 | COPTISINE | EC50 | = | 18490.0 | nM | 4.73 |