Assay Detail
Binding
CHEMBL5583007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of ThT from human G4-quadruplex Bcl2 DNA 5'- CGGGCGCGGGAGGAAGGGGGCGGGAGC-3' incubated for 0.5 hrs by SpectraMax M2 microplate reader analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A Comparative Study on the DNA Interactions and Biological Activities of Benzophenanthridine and Protoberberine Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.11 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362071 | COPTISINE | — | 1 | 6.46 |
| CHEMBL417799 | SANGUINARIUM | 2.0 | 1 | 6.36 |
| CHEMBL5593587 | — | — | 1 | 6.18 |
| CHEMBL13045 | CHELERYTHRINE | — | 1 | 6.07 |
| CHEMBL176008 | NITIDINE | — | 1 | 5.82 |
| CHEMBL295124 | BERBERINE | 4.0 | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362071 | COPTISINE | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL417799 | SANGUINARIUM | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL5593587 | — | Kd | = | 660.0 | nM | 6.18 |
| CHEMBL13045 | CHELERYTHRINE | Kd | = | 860.0 | nM | 6.07 |
| CHEMBL176008 | NITIDINE | Kd | = | 1520.0 | nM | 5.82 |
| CHEMBL295124 | BERBERINE | Kd | = | 1840.0 | nM | 5.74 |