Assay Detail
Binding
CHEMBL5583140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 6his-tagged N/C-terminal CHIKV nsP2 (1009 to 1329 residues) extracted from Escherichia coli Rosetta2 (DE3) cells preincubated with compound for 30 mins followed by peptide substrate addition and measured after 1.5 hrs by fluorescence based microplate reader analysis
77
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chikungunya virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyprotein P1234 (CHEMBL4295622) ↗| Type | SINGLE PROTEIN |
| Organism | Chikungunya virus (strain S27-African prototype) (CHIKV) |
Publication
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of <i>Chikungunya</i> nsP2 Cysteine Protease with Antialphavirus Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 77 | 6.34 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5594820 | — | — | 1 | 7.60 |
| CHEMBL5591218 | — | — | 1 | 7.60 |
| CHEMBL5594389 | — | — | 1 | 7.50 |
| CHEMBL5592235 | — | — | 1 | 7.40 |
| CHEMBL5593311 | — | — | 1 | 7.40 |
| CHEMBL5590710 | — | — | 1 | 7.30 |
| CHEMBL5594031 | — | — | 1 | 7.30 |
| CHEMBL5591355 | — | — | 1 | 7.30 |
| CHEMBL5594644 | — | — | 2 | 7.22 |
| CHEMBL5591247 | — | — | 1 | 7.20 |
| CHEMBL5590458 | — | — | 1 | 7.20 |
| CHEMBL5594942 | — | — | 1 | 7.20 |
| CHEMBL5592413 | — | — | 1 | 7.20 |
| CHEMBL5583713 | — | — | 1 | 7.20 |
| CHEMBL5592484 | — | — | 1 | 7.10 |
| CHEMBL5592232 | — | — | 1 | 7.10 |
| CHEMBL5595956 | — | — | 1 | 7.10 |
| CHEMBL5594152 | — | — | 1 | 7.10 |
| CHEMBL5595183 | — | — | 1 | 7.00 |
| CHEMBL5583848 | — | — | 1 | 7.00 |
| CHEMBL5595846 | — | — | 1 | 7.00 |
| CHEMBL5595857 | — | — | 1 | 6.90 |
| CHEMBL5593893 | — | — | 1 | 6.90 |
| CHEMBL5594785 | — | — | 2 | 6.80 |
| CHEMBL5595202 | — | — | 1 | 6.80 |
| CHEMBL5593604 | — | — | 1 | 6.80 |
| CHEMBL5591738 | — | — | 1 | 6.70 |
| CHEMBL5593852 | — | — | 1 | 6.70 |
| CHEMBL5594456 | — | — | 1 | 6.60 |
| CHEMBL5592833 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5594820 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5591218 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5594389 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL5593311 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5592235 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5590710 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5594031 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5591355 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5594644 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5583713 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5594942 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5592413 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5590458 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5591247 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5594644 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5594152 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5595956 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5592232 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5592484 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5595183 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5595846 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5583848 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5595857 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5593893 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5595202 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5593604 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5594785 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5591738 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5593852 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5594456 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5592833 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5595906 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5595171 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5594584 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5590160 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5592719 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5592345 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5593841 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5591125 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5589821 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5592867 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5595573 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5595412 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5593224 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5592616 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5591529 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5592094 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5593248 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5593346 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5593154 | — | IC50 | = | 1000.0 | nM | 6.00 |