Assay Detail
Binding
CHEMBL5583155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FGFR3/BAIAP2L1 (unknown origin) transduced in mouse BaF3 cells incubated for 48 hrs by Cell Titer Glo assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.90 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828009 | LY-2874455 | 1.0 | 1 | 9.70 |
| CHEMBL5594526 | — | — | 1 | 9.10 |
| CHEMBL5593614 | — | — | 1 | 8.60 |
| CHEMBL3545376 | ERDAFITINIB | 4.0 | 1 | 8.59 |
| CHEMBL5593800 | — | — | 1 | 8.49 |
| CHEMBL5589661 | — | — | 1 | 8.44 |
| CHEMBL5595860 | — | — | 1 | 8.39 |
| CHEMBL5590027 | — | — | 1 | 8.28 |
| CHEMBL5591286 | — | — | 1 | 8.24 |
| CHEMBL5591378 | — | — | 1 | 8.22 |
| CHEMBL5595732 | — | — | 1 | 8.22 |
| CHEMBL5592858 | — | — | 1 | 8.21 |
| CHEMBL5595265 | — | — | 1 | 8.20 |
| CHEMBL5593851 | — | — | 1 | 8.19 |
| CHEMBL5594411 | — | — | 1 | 8.09 |
| CHEMBL5592556 | — | — | 1 | 8.07 |
| CHEMBL5584069 | — | — | 1 | 8.06 |
| CHEMBL5593595 | — | — | 1 | 8.00 |
| CHEMBL5595500 | — | — | 1 | 7.96 |
| CHEMBL5595947 | — | — | 1 | 7.96 |
| CHEMBL5595996 | — | — | 1 | 7.92 |
| CHEMBL5592315 | — | — | 1 | 7.89 |
| CHEMBL5594702 | — | — | 1 | 7.89 |
| CHEMBL5590817 | — | — | 1 | 7.85 |
| CHEMBL5595644 | — | — | 1 | 7.85 |
| CHEMBL5593620 | — | — | 1 | 7.80 |
| CHEMBL5592211 | — | — | 1 | 7.80 |
| CHEMBL5594093 | — | — | 1 | 7.80 |
| CHEMBL5594121 | — | — | 1 | 7.77 |
| CHEMBL5594646 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828009 | LY-2874455 | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5594526 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5593614 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3545376 | ERDAFITINIB | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5593800 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5589661 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5595860 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5590027 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5591286 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5591378 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5595732 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5592858 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5595265 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5593851 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5594411 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5592556 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5584069 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5593595 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5595500 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5595947 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5595996 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5594702 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5592315 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5590817 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5595644 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5593620 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5592211 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5594093 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5594121 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5594646 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5583622 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5595795 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5594474 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5594509 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5594268 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5594969 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5590821 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5595523 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5584096 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5594925 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5592520 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5594374 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5593408 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5593361 | — | IC50 | = | 179.0 | nM | 6.75 |