Compound Detail
CHEMBL5594374
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Basic Information
| ChEMBL ID | CHEMBL5594374 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UKDOWXSLSIGSNR-SNVBAGLBSA-N |
2
Targets
5
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
419.7
MW (Da)
6.12
ALogP
4
HBA
1
HBD
63.7
PSA (Ų)
0.40
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.96
Target Activity Profile
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| t1/2 | - | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 110.0 | nM | 6.96 | Inhibition of recombinant FGFR3/BAIAP2L1 (unknown origin) transduced in mouse Ba... | 39258897 |
| Unchecked | IC50 | = | 451.0 | nM | 6.35 | Inhibition of recombinant BCR/FGFR2 (unknown origin) transduced in mouse BaF3 ce... | 39258897 |
| TEL/KDR | IC50 | = | 864.0 | nM | 6.06 | Inhibition of recombinant TEL/VEGFR2 (unknown origin) transduced in mouse BaF3 c... | 39258897 |
| Unchecked | IC50 | = | 1043.0 | nM | 5.98 | Inhibition of recombinant BCR/FGFR1 (unknown origin) transduced in mouse BaF3 ce... | 39258897 |
| Unchecked | IC50 | = | 2198.0 | nM | 5.66 | Inhibition of recombinant BCR/FGFR4 (unknown origin) transduced in mouse BaF3 ce... | 39258897 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39258897 | 10.1021/acs.jmedchem.4c01531 | Unchecked | 5 |
| 39258897 | 10.1021/acs.jmedchem.4c01531 | TEL/KDR | 1 |
| 39258897 | 10.1021/acs.jmedchem.4c01531 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine