Assay Detail
Binding
CHEMBL5584574
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Binding affinity to TTRG3 G-quadruplex (unknown origin) assessed as dissociation constant by fluorescence spectroscopy
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Characterization of the G-quadruplexes in the transthyretin gene and its role in silencing transthyretin mRNA transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.30 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5589886 | — | — | 1 | 8.28 |
| CHEMBL2170855 | — | — | 1 | 6.83 |
| CHEMBL4094858 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5589886 | — | Kd | = | 5.3 | nM | 8.28 |
| CHEMBL2170855 | — | Kd | = | 147.9 | nM | 6.83 |
| CHEMBL4094858 | — | Kd | = | 166.6 | nM | 6.78 |