Assay Detail
Binding
CHEMBL5584747
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Inhibition of DPP4 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and clinical application of representative small-molecule dipeptidyl Peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus (T2DM).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.49 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | 4.0 | 1 | 9.00 |
| CHEMBL5597715 | — | — | 1 | 8.64 |
| CHEMBL2105754 | TRELAGLIPTIN SUCCINATE | 4.0 | 1 | 8.40 |
| CHEMBL4646510 | COFROGLIPTIN | 2.0 | 1 | 8.38 |
| CHEMBL1201174 | SITAGLIPTIN PHOSPHATE | 4.0 | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5597715 | — | IC50 | = | 2.27 | nM | 8.64 |
| CHEMBL2105754 | TRELAGLIPTIN SUCCINATE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4646510 | COFROGLIPTIN | IC50 | = | 4.18 | nM | 8.38 |
| CHEMBL1201174 | SITAGLIPTIN PHOSPHATE | IC50 | = | 9.0 | nM | 8.05 |