Compound Detail
CHEMBL2105754
TRELAGLIPTIN SUCCINATE 💊 Approved Drug
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💊 Approved Drug
Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2cc(F)ccc2C#N)c1=O.O=C(O)CCC(=O)O
Basic Information
| ChEMBL ID | CHEMBL2105754 |
| Name | TRELAGLIPTIN SUCCINATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | OGCNTTUPLQTBJI-XFULWGLBSA-N |
| Parent Compound | CHEMBL1650443 |
| Active Moiety | CHEMBL1650443 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
5
Known Names
2
Indications
1
Mechanisms
Molecular Properties
357.4
MW (Da)
0.53
ALogP
7
HBA
1
HBD
97.0
PSA (Ų)
0.86
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2015 |
| Availability | Unknown |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Dipeptidyl peptidase IV inhibitor | INHIBITOR | Dipeptidyl peptidase 4 | ✓ | ✓ |
Indications
Diabetes Mellitus Diabetes Mellitus, Type 2
Activity Summary
IC50 1 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of DPP4 (unknown origin) | 38704940 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38704940 | 10.1016/j.ejmech.2024.116464 | Dipeptidyl peptidase 4 | 1 |
Data from ChEMBL 36 via Core Engine